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“Healthy circulation requires proper blood thickness and flexible blood vessels. My improved NattoPlus formula addresses both with clinically researched ingredients that keep your blood flowing smoothly throughout your body.” —Stephen Sinatra, M.D.
Your vascular system is a lifeline for your body, delivering critical nutrients and oxygen to every cell and carrying out waste. To improve circulation and promote healthy blood pressure, you need both strong, capable vessels and proper blood viscosity.
Dr. Sinatra’s NEWLY REFORMULATED NattoPlus offers stronger-than-ever support for every aspect of healthy circulation.
Improved NattoPlus:
Provides stronger defense against inflammation with powerful
NEW Meriva
Naturally thins your blood to improve circulation
Promotes strong, flexible blood vessels
Supports proper fibrin function and normal clotting
Promotes healthy blood pressure
Breakthrough Defense Against Inflammation
Dr. Sinatra’s exclusive NattoPlus formula now features an all new patented turmeric extract called Meriva® that offers powerful protection against inflammation throughout your circulatory system and support for healthy blood vessels.
Science Meets Nature in This Inflammation-Fighting Superstar
The Meriva Miracle starts with an ordinary house spice called turmeric (Curcuma longa). Curcumin is turmeric’s active ingredient and you’ll recognize it as the substance that gives curry and mustard their distinctive taste and color.
Curcumin has been used for thousands of years as a healing agent but recent research studies have also shown it to be a potent antioxidant with the ability to neutralize even the most harmful free radicals. Unfortunately, curcumin is notoriously hard for the human body to absorb.
But now scientists have discovered a way to attach curcumin to certain enzymes that are part of ordinary human cells, making it easily absorbable. This revolutionary new nutrient is called Meriva Curcumin Phytosome and it’s 45 times better absorbed than ordinary curcumin for unprecedented antioxidant protection against free radical stress throughout your body, including your circulatory system.Fights Fibrin Buildup
Plus, NattoPlus provides you with nattokinase—nature’s very own blood thinner. It’s an all-natural soybean extract that’s known to support healthy blood pressure and improve circulation to every part of your body, so you can feel young and energized.
Click here to find out how.
Dr. Sinatra’s NattoPlus formula includes proprietary NSK-SD® nattokinase, which is the only nattokinase shown in clinical research to naturally thin your blood, keep your blood vessels open, and support smooth blood flow. Plus, it’s far more potent than other leading nattokinase products on the market.

All in all, the Meriva, NSK-SD nattokinase, and additional antioxidant ingredients in NattoPlus work together to promote healthy blood pressure and improve circulation for total circulatory system support.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
| Dosage | Dosage: Adults: Take 2 capsules twice daily before morning and evening meals. Children: This product is not recommended for children. |
| Ingredients List | Lemon BioFlavonid Complex, Magnesium, Nattokinase, Turmeric, Vitamin C |
| Pill Type | Capsules |
| Warnings | Do not take this product if you take Coumadin (Warfarin) or other blood-thinning products. Pregnant or lactating women should consult a health care professional before using this product. CONTAINS: SOY |
What are the ingredient standardizations?
Nattokinase: 20,000 FU per gram
Is the formula kosher?
No
Is the formula and capsule vegetarian?
No, the gelatin found in the capsule is made from bovine (cow) and porcine (pig) sources. Our capsules are all pharmaceutical grade, and are made from the same gelatin that is used by leading pharmaceutical companies.
Is the formula sodium free?
Yes.
What are the “other ingredients” used in this product?
We fully disclose all the ingredients used in the manufacturing of our products, including the excipients, fillers and machinery lubricants. These are listed as “other ingredients” on the label:
Gelatin(capsule), microcrystalline cellulose (filler), magnesium stearate (vegetable grade/machinery lubricant), silicon dioxide (flow agent).
Which of the ingredients are natural and which are synthetic?
All of the ingredients are naturally sourced. We also use no preservatives, artificial colors or artificial flavors.
Can I take this product with Dr. Sinatra’s other recommended nutritional supplements?
Yes, except Dr. Sinatra does not recommend taking NattoPlus with Daily BP Support due to the additive blood pressure effects.
How should I store the product?
To preserve the quality and freshness, keep the bottle tightly closed and store it in a cool, dry place (59°-86°F). Do not refrigerate.
Supplements should not be stored in the kitchen or bathroom as the higher levels of heat and moisture can lower its potency and stability over time.
Are my supplements still safe and/or effective if the package was left outside in the heat or cold for a couple of days?
Yes, there is no concern for safety or potency of your supplements if they were mistakenly left outside in the heat or cold for a short period of time (2-3 days), or for an extended period during shipping. It takes months of improper storage to negatively affect the quality of the product.
Is this product tested for lead, mercury, and other heavy metals?
Every batch of Healthy Directions’ products is tested for lead and heavy metals. Each is delivered to Healthy Directions with a Certificate of Analysis from the manufacturer stating that the products are free from heavy metals or within the limits set by California’s Proposition 65 – the most stringent in the country.
Does this product undergo independent laboratory testing?
Each month, Healthy Directions selects several of its products and sends them to independent laboratories to make sure that they meet safe levels for heavy metals as well as label claim. Each product is guaranteed to be tested at least once per year.



