Medications That Deplete CoQ10 & the CoQ10 Dosage You Need

Filed Under: Heart Health, CoQ10, Nutrients and Additives

Medications That Deplete CoQ10 & the CoQ10 Dosage You Need

Are you taking a medication that's depleting your body's CoQ10? Find out now, along with the CoQ10 dosage you need.

I have long considered coenzyme Q10 (CoQ10) to be one of the most powerful heart vitamins because of its ability to help prevent cardiovascular problems, including heart attack and stroke.

Why does your body need CoQ10? The heart is one of the few organs in the body to function continuously without resting; therefore, the heart muscle (myocardium) requires the highest level of energetic support. Any condition that causes a decrease in CoQ10 could impair the energetic capacity of the heart, thus leaving the tissues more susceptible to free radical attack.

One of the biggest factors that can deplete your body's CoQ10 supply is precription medications. If you have cardiovascular problems, you may be taking prescription drugs to help you manage them. But while most people know there can be side effects from drugs, you may be among the many who don’t realize that medication interactions can affect other medications, supplements and even food.

These medication interactions can drain vital nutrients from your body and counteract the healing powers of the drugs. As you age, your nervous system becomes more sensitive, and you are more prone to developing side effects. The more medications you take, the more likely it is that adverse reactions will occur.

Which Drugs Can Rob You of CoQ10 Benefits?

Certain drugs can deplete your body's CoQ10 supply by interfering with CoQ10-dependent enzymes, lowering its concentration in the body. I’ve seen many patients who are deficient in this nutrient. Listed below are some prescription drugs that can cause a CoQ10 deficiency.

Get more of Dr. Sinatra's advice on CoQ10

Antidiabetic Drugs

  • Sulfonylureas
  • Acetohexamide
  • Glyburide
  • Tolazamide
  • Tolbutamide
  • Glipizide
  • Glimepiride
  • Chlorpropamide

Psychotherapeutic Drugs

  • Tricyclic Antidepressants
  • Amitriptyline
  • Desipramine
  • Nortriptyline
  • Doxepin
  • Imipramine
  • Phenothiazines
  • Chlorpromazine
  • Thioridazine
  • Fluphenazine
  • Butyrophenones
  • Haloperidol

Heart Medications

If you see doctors and holistic health practitioners and don’t tell each one of them every drug you take, they can unknowingly prescribe medications that interact adversely with something you’re already taking. Keep a list of all your drugs and supplements, such as a CoQ10 supplement, and take it with you to every doctor’s appointment.

The CoQ10 Dosage You Need to Restore Your Body's CoQ10 Supply

There's no question that CoQ10 is one of the most powerful heart vitamins. For general heart health, I recommend a CoQ10 dosage of of 50-100 mg daily. But if you're on a cholesterol-lowering statin drug, or are over 60, I recommend a CoQ10 dosage of 100-200 mg daily. But if you have congestive heart failure or a recent heart attack or heart surgery, you want to take 200-300 mg of CoQ10 daily.

If your response to your initial dose is less than optimal, work with your physician or holistic health practitioner to increase the CoQ10 supplement dosage and maintain it over time. As with most nutritional supplements, it is best to take CoQ10 supplements in divided doses with your meals.

Read More About CoQ10

Coenzyme Q10: Benefits of CoQ10 & the Right CoQ10 Dosage
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To Get the Right CoQ10 Dosage You Can't Always Trust the Label
Discover why many CoQ10 supplements don't deliver the full CoQ10 dosage that's listed on the label, and get Dr. Sinatra's top tips for spotting a high-quality supplement that delivers the best CoQ10 benefits. Read more
The Right CoQ10 Dosage—Separating the Myths from the Facts
The good news about coenzyme Q10 (CoQ10) is that more people than ever know they should be taking it, but taking the right CoQ10 dosage can be tougher than many people think. Read more
Metabolic Cardiology—a Powerful Treatment for Congestive Heart Failure
Discover why metabolic cardiology is a powerful treatment for congestive heart failure and the top nutrients Dr. Sinatra recommends for restoring the heart. Read more


DISCLAIMER: The content of is offered on an informational basis only, and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified health provider before making any adjustment to a medication or treatment you are currently using, and/or starting any new medication or treatment. All recommendations are "generally informational" and not specifically applicable to any individual's medical problems, concerns and/or needs.

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