One-of-a-kind Restorative Sleep™ improves sleep quality, supports brain and cognitive health and your body's natural detoxification processes

Restorative Sleep (30 tablets, 1-month supply)

Item# SRS

 

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One-of-a-kind Restorative Sleep™ leaves your body refreshed and your mind sharp!

  • Calms and relaxes your body and mind so you fall asleep quickly and stay asleep
  • Supports brain health and cognitive function
  • Helps maintain heart and brain health with antioxidants
  • Helps support your body’s natural detoxification processes
  • Melatonin helps reset your natural sleep cycle for a sound sleep—every night
  • Developed by integrative cardiologist Dr. Stephen Sinatra

A good night’s sleep, combined with a healthy lifestyle, can have a positive effect on everything from your immune system to your blood pressure, weight, blood sugar, alertness, mood…the list goes on and on. Restorative Sleep helps to calm and relax your mind for a sound night’s sleep, giving your body the time it needs to repair and rejuvenate overnight so you feel rested and alert for the days ahead.

The truth is that while you sleep, your body is working to restore and rejuvenate itself, repairing damage caused by daily activities, storing and processing new memories, and balancing out the stress of everyday life. That’s why deep sleep is essential for true health—but declining levels of melatonin (the “sleep hormone”) and shifts in circadian rhythms make it harder and harder to sleep well as you age.

And while typical sleep aids may help you get a few more winks at night, Restorative Sleep goes further—making sure you fall asleep quickly and stay asleep longer, so you wake up feeling rested, refreshed, and more mentally sharp than when you went to sleep. Plus, the nutrients in Restorative Sleep work to support your body’s natural detoxification processes—something we all need, every day!

Restorative Sleep word cloud

Restorative Sleep is designed to support the natural benefits of your sleeping hours, your cognitive performance, and your body’s own repair mechanisms while you sleep soundly.

Quality sleep and a sharper mind, too!

One of the unique ingredients in Restorative Sleep is clinically studied, highly bioavailable LONGVIDA® Optimized Curcumin Extract. This remarkable extract helps support cognitive function, reduce mental fatigue, and support overall brain health. LONGVIDA has been clinically shown to:

  • Improve sustained attention and working memory, and reduce performance errors
  • Help maintain alertness and reduce mental fatigue
  • Help maintain calmness and contentedness

Quiet a racing mind and reset your natural sleep cycle

To help prepare your body for sleep and deliver a sound night’s sleep, Restorative Sleep also features calming PharmaGABA® and sleep-inducing melatonin.

Because melatonin levels decline significantly with age—and nighttime levels of cortisol (the “stress hormone”) begin to rise—sound sleep becomes a real challenge. Restorative Sleep helps restore the balance of these hormones to bring back peaceful sleep.

PharmaGABA is a naturally produced form of the important brain amino acid GABA, which relaxes your mind to help prepare your body for rest. Research indicates PharmaGABA increases the production of alpha brain waves that indicate a state of relaxation.

I’ve also included 1 mg of melatonin, which regulates your body’s natural sleep cycle and helps induce REM sleep. Taking melatonin nightly helps tell your body it’s time to go to sleep, and helps you get a better night’s sleep

The Circadian Battle That’s Keeping You Awake

As we age, our levels of sleep-inducing melatonin decline, and our production of stress-related cortisol begins ramping up in the overnight hours. As a result, we begin to awaken more easily during the night or have trouble falling back asleep after waking. Restorative Sleep delivers a researched dose of melatonin to help you sleep more soundly and PharmaGABA to help calm and ready you for sleep.

Antioxidants help your cells repair and rejuvenate

Did you know that the act of sleeping itself is a powerful antioxidant? It’s true—one of the reasons sleep is so critical for overall health is that sleeping helps reduce the oxidative stress that naturally occurs around the clock and causes cellular damage.

Restorative Sleep takes this natural benefit of sleep two steps further with its remarkable antioxidant blend of astaxanthin and N-Acetyl-L-Cysteine (NAC). This powerful duo gives your body extra help managing oxidative stress and inflammation, which is essential for a healthy heart! Plus, it helps to support your body’s natural detoxification processes.

Specifically, I’m excited about NAC, which is a precursor to glutathione—a “master antioxidant” and one of the most potent antioxidants in your mitochondria, which is where a large number of oxidants are generated. By maintaining sufficient levels of glutathione, your body is armed with its greatest defense against oxidative stress by neutralizing free radicals your body encounters from both internal and external sources throughout the day. This in turn helps support your body’s natural detoxification processes—something we all need every day!

Overall, Restorative Sleep combines these potent, clinically studied and tried-and-true ingredients to help calm and relax your mind for a sound night’s sleep, giving your body the time it needs to repair, restore, and rejuvenate so you feel rested and alert for the days ahead.

Dr. Sinatra Says:

Dr. Stephen Sinatra
 

"Important healing and repair processes take place when we sleep. That’s why I can’t stress enough just how important it is to get a good night’s sleep is. I’m excited to have found a way to deliver the restorative sleep you need, on a consistent basis that not only helps you wake up refreshed, but also helps support brain and cognitive health and your body’s natural detoxification processes."

 
 
The Circadian Battle That’s Keeping You Awake

As we age, our levels of sleep-inducing melatonin decline, and our production of stress-related cortisol begins ramping up in the overnight hours. As a result, we begin to awaken more easily during the night or have trouble falling back asleep after waking. Restorative Sleep delivers a researched dose of melatonin to help you sleep more soundly and PharmaGABA to help calm and ready you for sleep.

Restorative Sleep word cloud

Restorative Sleep is designed to support the natural benefits of your sleeping hours, your cognitive performance, and your body’s own repair mechanisms while you sleep soundly.


Dr. Sinatra Says:

Dr. Stephen Sinatra
 

"Important healing and repair processes take place when we sleep. That’s why I can’t stress enough just how important it is to get a good night’s sleep is. I’m excited to have found a way to deliver the restorative sleep you need, on a consistent basis that not only helps you wake up refreshed, but also helps support brain and cognitive health and your body’s natural detoxification processes."

 
 

Ingredients and Dosage

Doctor's Suggested Use: Take 1 tablet approximately 30–60 minutes prior to going to bed.

Serving Size: 1 Tablet
Servings Per Container: 30

Ingredient Amount Per Serving % DV
LONGVIDA®‡ Optimized Turmeric Extract (Curcuma longa, root) 400 mg *
N-Acetyl-L-Cysteine 200 mg *
PharmaGABA®§ Gamma-Amino Butyric Acid (from fermentation) 50 mg *
AstaReal®♦ Astaxanthin (from algae) 1 mg *
Melatonin 1 mg *
*Daily Value (DV) not established

Other ingredients: Microcrystalline cellulose, maltodextrin, dicalcium phosphate, croscarmellose sodium, stearic acid, crospovidone, magnesium stearate, shellac, talc, silicon dioxide, hydroxypropyl methylcellulose, glycerin, triacetin

CONTAINS: SOY

WARNING: Do not drive or operate heavy machinery while using this product. Pregnant or lactating women or those who are trying to become pregnant should avoid melatonin.
Keep out of reach of children.

LONGVIDA® is patent protected under EP 1993365, other patents pending and a registered trademark of Verdure Sciences Inc.

§PharmaGABA® is a registered trademark of Pharma Foods International Co., Ltd. (Japan)

AstaReal® is a registered trademark of Fuji Health Sciences.

Batch Information

Science and Quality

The clinically studied and tried-and true ingredients in Restorative Sleep help you sleep more soundly, support brain health and cognitive performance, and allow your body to rest and repair while you sleep.

Melatonin (1 mg)

Melatonin is a hormone released by the pineal gland at night that helps dictate sleep patterns. Around the age of 40, adults begin to experience declines in their melatonin secretions. Senior adults typically have lower melatonin levels and altered melatonin patterns, exhibiting longer periods until melatonin is excreted at night (i.e., longer time to fall asleep) and extended patterns of secretion that extend its release into the daytime hours (i.e., sleeping during the day).1

In a 4-week double-blind, placebo-controlled research study, 26 healthy elderly subjects (aged 64–89) were given either 1 mg melatonin or placebo each night. Researchers found that melatonin administration at a dosage of 1 mg nightly may be effective in improving certain aspects of cognitive functioning as well as sleep quality.2

LONGVIDA® Optimized Curcumin Extract [from Curcuma longa root] (400mg)

Turmeric (Curcuma longa) has been used for thousands of years as a spice, a coloring agent, and a traditional medicine used to combat inflammation. Turmeric contains curcumin, a spice shown to be an effective antioxidant, scavenging free radicals. Recent research also indicates significant cognitive benefits of curcumin.

Unfortunately, ordinary curcumin extracts are extremely difficult to absorb. LONGVIDA is an enhanced curcumin extract developed at UCLA by neuroscientists that utilizes a cutting-edge SLCP™ Technology to deliver free curcumin into target tissues through enhanced bioavailability.

In a randomized, double-blind, placebo-controlled parallel group trial, 60 healthy adults (60–84 years old) were randomly assigned 400 mg/day of LONGVIDA or identical placebo for 30 days to analyze the effects of LONGVIDA on cognitive function/performance and mood using the Computerized Mental Performance Assessment System (COMPASS) and State-Trait Anxiety Inventory (STAI-S).3 LONGVIDA demonstrated improved measurements in cognitive function after acute and long-term dosing and mood after long-term supplementation. These improved measures of fatigue, alertness, calmness, contentment, attention, and working memory show LONGVIDA’s beneficial effect on mental status in a healthy older population.

Cognitive and mood assessments included Serial Subtraction (Serial Three Subtraction and Serial Seven Subtraction)—a mental arithmetic stress task used to evaluate working memory, focus, and attention. Serial subtraction is known to stimulate activity in areas of the brain responsible for executive functions, or higher order cognitive processes such as memory and problem solving, including the frontal cortex, the parietal cortex, and the motor area.

  • Accuracy: In subjects taking an arithmetic test, LONGVIDA showed a significantly greater number of correct responses after one hour on the first day and after 30 days.
  • Reaction Time: The LONGVIDA group also showed a significant improvement in reaction time, on both day one and after 30 days taking LONGVIDA.
  • Accuracy: On day one the number of correct responses increased by 12% on Longvida while placebo declined by 2% after 1 hour.
  • Alertness: Scores of alertness tend decline significantly during cognitive testing. On day 30 of testing, subjects in the placebo group noted a significant decline in their subjective feeling of alertness at one hour and three hours, while there was no significant change in alertness among the treatment group. This suggests that 30-day dosing of LONGVIDA may help maintain alertness during prolonged tasks requiring concentration.
  • Calm and Contentedness: Additional tests revealed significant improvements in mental energy, calmness, and contentedness.
  • Antioxidant Benefits: A second placebo-controlled study4 demonstrated that LONGVIDA promoted numerous effects in healthy middle aged adults ranging from antioxidant support to supporting normal levels of markers associated with heart, liver, and brain health.

PharmaGABA® (50 mg)

GABA (Gamma Amino Butyric Acid) is an amino acid and is the chief inhibitory (“calming”) neurotransmitter in the central nervous system. It plays a critical role in transmitting neural signals throughout the body. PharmaGABA is a naturally produced form of GABA. It is a non-habit-forming nutrient that helps relax your mind and prepare your body for rest.

In a single blind, crossover trial over 3 weeks, 30 subjects consumed a beverage with 0, 25, or 50 mg before being assigned to take an arithmetic task. Chromogranin A (CgA), a marker of immune health which is lowered by stress, was also measured.5 PharmaGABA-containing beverages helped reduce the perception of psychological fatigue and physical fatigue leading to an improvement in ability to perform task-solving. The conclusion is that PharmaGABA:

  • Helps reduce mental fatigue
  • Helps lower perception of mental fatigue
  • Helps increase levels of chromogranin A (CgA), a marker of immune health.
  • Helps reduce levels of cortisol, a hormone associated with stress
  • Helps improve accuracy when completing mentally challenging tasks.

Research performed at double the dose (100 mg) of PharmaGABA:

In a small placebo-controlled study using an electroencephalogram (EEG), brain waves were evaluated in 13 subjects after either intake of PharmaGABA, water, or theanine.6

  • The EEG found that 60 minutes after taking 100 mg of PharmaGABA (the amount found in a double dose of Restorative Sleep), subjects showed higher α waves and lower β waves than either placebo or theanine. These findings suggest that GABA can induce relaxation as well as reduce the perception of stress and anxiety.

In a small blinded study, 8 people with a fear of heights were subjected to crossing a tall suspension bridge after taking either PharmaGABA or placebo.

  • Those taking 100 mg GABA from PharmaGABA (the amount found in a double dose of Restorative Sleep) experienced slightly lower IgA levels (an antibody associated with stress and anxiety) at the middle of the bridge to significantly higher levels at the end of the bridge. A significant decrease of IgA levels was found in saliva of placebo group at the middle and end of the bridge.7 PharmaGABA reduced the perception of stress and anxiety as well as supported a positive mood via IgA measurements.

Astaxanthin (1 mg)

Research performed at double the dose (2 mg) of Astaxanthin:

Astaxanthin is a powerful antioxidant that has protective and immune-supporting benefits. In an 8-week randomized, double-blind, placebo-controlled clinical study with 14 healthy female subjects, 2 mg/day astaxanthin significantly reduced CRP (a marker of inflammation), increased immune defense cells (T- and B- cells), and skin delayed-type hypersensitivity (DTH), a measure of immune health.8

N-Acetyl-L-Cysteine (200 mg)

N-Acetyl-L-Cysteine serves as a precursor of glutathione, known as the body’s “master antioxidant.”


1 Zhou JN, et al. J Pineal Res. 2003;34(1):11–16.
2 Peck JS, et al. Am J Geriatr Psychiatry. 2004 Jul–Aug;12(4):432–6.
3 Cox K, et al. Journal of Psychopharmacology. 2014 (Accepted, in publication)
4 DiSilvestro R, et al. Nutrition Journal. 2012;11(79): 1–8.
5 Kanehira T, et al. J Nutr Sci Vitaminol. 2011;57:9–15.
6 Abdou AM et al. Biofactors. 2006;26:201–8.
7 Abdou AM et al. Biofactors. 2006;26:201–8.
8 Park JS, et al. Nutr Metab (Lond). 2010;7:18.

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Product Quality

  • Manufactured to exacting standards using highest quality raw materials
  • Produced in accordance with our strict Standard Operating Procedures (SOPs) that meet or exceed those set by the FDA’s Good Manufacturing Practices
  • Every batch tested to verify purity and potency specifications are met
  • Quality assured with our Triple-Testing Philosophy™
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