Japanese secret promotes healthy blood circulation with potent natural anti-inflammatory powers

NattoPlus (120 capsules, 30-day supply) | circulatory health supplements

Item# CAS
1 Bottle
Buy 3, Get 1 FREE
Was: $139.96
Now: $104.97
Buy 5, Get 2 FREE
Was: $244.93
Now: $174.95

“Healthy circulation requires proper blood thickness and flexible blood vessels. My improved NattoPlus formula addresses both with clinically researched ingredients that keep your blood flowing smoothly throughout your body.” —Stephen Sinatra, M.D.

Your vascular system is a lifeline for your body, delivering critical nutrients and oxygen to every cell and carrying out waste. To improve circulation and promote healthy blood pressure, you need both strong, capable vessels and proper blood viscosity. My NattoPlus offers stronger-than-ever support for every aspect of healthy circulation.


  • Provides stronger defense against inflammation with powerful Meriva
  • Naturally thins your blood to improve circulation
  • Promotes strong, flexible blood vessels
  • Supports proper fibrin function and normal clotting
  • Promotes healthy blood pressure

Breakthrough Defense Against Inflammation

My unique NattoPlus formula now features a patented turmeric extract called Meriva® that offers powerful protection against inflammation throughout your circulatory system and support for healthy blood vessels.

The Meriva Miracle

Science Meets Nature in This Inflammation-Fighting Superstar. The Meriva Miracle starts with an ordinary house spice called turmeric (Curcuma longa). Curcumin is turmeric’s active ingredient and you’ll recognize it as the substance that gives curry and mustard their distinctive taste and color. Curcumin has been used for thousands of years as a healing agent but recent research studies have also shown it to be a potent antioxidant with the ability to neutralize even the most harmful free radicals. Unfortunately, curcumin is notoriously hard for the human body to absorb. But now scientists have discovered a way to attach curcumin to certain enzymes that are part of ordinary human cells, making it easily absorbable. This revolutionary new nutrient is called Meriva Curcumin Phytosome and it’s 45 times better absorbed than ordinary curcumin for unprecedented antioxidant protection against free radical stress throughout your body, including your circulatory system.

Fights Fibrin Buildup

NSK-SD Nattokinase Natural Blood Thinning Break Through chart to show improve circulation

Plus, NattoPlus provides you with nattokinase—nature’s very own blood thinner. It’s an all-natural soybean extract that’s known to support healthy blood pressure and improve circulation to every part of your body, so you can feel young and energized.

My NattoPlus formula includes a proprietary non-GMO form of nattokinase called NSK-SD®. It is the only nattokinase shown in clinical research to naturally thin your blood, keep your blood vessels open, and support smooth blood flow. Plus, it’s far more potent than other leading nattokinase products on the market.

All in all, the Meriva, NSK-SD nattokinase, and additional antioxidant ingredients in NattoPlus work together to promote healthy blood pressure and improve circulation for total circulatory system support.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Ingredients & Dosage

Nattoplus: 2 capsules give you...

Vitamin C (as magnesium ascorbate) 258 mg
Magnesium (as ascorbate, glycinate) 50 mg
L-Arginine (as HCI) 500 mg
Nattokinase (from non-GMO soy)‡ 50 mg
Citrus Bioflavonoid Complex 50 mg
Meriva® Curcumin Phytosome♦.
Turmeric Extract (rhizome),
Phosphatidylcholine (from soy)
50 mg

Other ingredients: Gelatin, microcrystalline cellulose, magnesium stearate, silicon dioxide

CONTAINS: Trace amounts of non-GMO soy to enhance bioavailability.

Standardization Levels: Nattokinase: 20,000 FU per gram

‡NSK-SD® is a registered trademark of JBSL.
♦Meriva® is a registered trademark of Indena S.p.A.

Take 2 capsules twice daily before morning and evening meals.
Note: This product is not recommended for children.

Allergy Information:
This product contains soy.

Side Effects:
There are no known side effects associated with this product. However, as with any food product, there may be infrequent and unusual highly sensitized reactions associated with this or any other nutritional supplement. If such a reaction occurs, you should consider discontinuing use of this or any product.

Do not take this product if you take Coumadin® (warfarin) or other blood thinning products.
Pregnant or lactating women should consult a health care professional before taking this product.
Keep out of reach of Children.


Displaying 1-10 of 18


Reviewed on
5.0 out of 5 stars

After taking NattoPlus, my blood pressure has reached low levels that I have never seen with just prescription pills. I feel great and youthful waking up mornings and I think that Natto is the reason. Thanks!


Reviewed on
5.0 out of 5 stars

Natto Plus is a wonderful product I am 81 years young and can do anything within reason that I want to do. I also take a low dose aspirin. Along with your Omega Q Plus keeps me in good shape.


Reviewed on
5.0 out of 5 stars

After my heart problem the Doctor prescribed a common drug to thin my blood (very close to rat poison). After 1 and half years on NattoPlus my blood is correct and I feel wonderful.


Reviewed on
5.0 out of 5 stars

The best observable Sinatra supplement! It thins out my blood and I have watched my blood pressure drop ever since I started taking it.


Reviewed on
5.0 out of 5 stars

This product works!! I have recommended it to several people who were having "issues" and they could tell a marked difference! I also take it myself - especially if I am not as active as I should be for prolonged times or sitting too long as in traveling.


Reviewed on
4.0 out of 5 stars

I have been taking NattoPlus for a few years now and I am confident that it is keeping my heart and arteries healthy after bypass surgery 7 years ago I feel good and have not had further problems with clogged arteries.


Reviewed on
5.0 out of 5 stars

I have been taking this for a few months. It seems to help my blood pressure stay within reasonable levels.


Reviewed on
5.0 out of 5 stars

Started taking this product after a [surgical] operation which I now wish I could take back. Had clot and infection problems during the process. That was 8 years ago and have not had any problems. Would highly recommend to anyone to replace the rat posion they want you to take.


Reviewed on
3.0 out of 5 stars

I gave it a 3 because I do not know if it is working. instead of taking aspirin and a beta blocker I am using this and other food sources such as garlic, magnesium and other such things plus Dr. Sinatra's heart formulas. So far, so good.


Reviewed on
5.0 out of 5 stars

NattoPlus is an excellent product. I have been taking it for sometime and have no problem with circulation. I am 80 years young and can do most anything that I want to do.

See why Dr. Sinatra partners with Healthy Directions

Product Quality

How do I know I am choosing the best supplements?

What are the ingredient standardizations?

Nattokinase: 20,000 FU per gram

Is the formula kosher?


Is the formula and capsule vegetarian?

No, the gelatin found in the capsule is made from bovine (cow) and porcine (pig) sources. Our capsules are all pharmaceutical grade, and are made from the same gelatin that is used by leading pharmaceutical companies. 

Is the formula sodium free?


What are the “other ingredients” used in this product?

We fully disclose all the ingredients used in the manufacturing of our products, including the excipients, fillers and machinery lubricants. These are listed as “other ingredients” on the label:

Gelatin (capsule), microcrystalline cellulose (filler), magnesium stearate (vegetable grade/machinery lubricant), silicon dioxide (flow agent).

Which of the ingredients are natural and which are synthetic?

All of the ingredients are naturally sourced. We also use no preservatives, artificial colors or artificial flavors.

Can I take this product with Dr. Sinatra’s other recommended   nutritional supplements?

Yes, except Dr. Sinatra does not recommend taking NattoPlus with Advanced BP Support due to the additive blood pressure effects.

How should I store the product?

To preserve the quality and freshness, keep the bottle tightly closed and store it in a cool, dry place (59°-86°F). Do not refrigerate.

Supplements should not be stored in the kitchen or bathroom as the higher levels of heat and moisture can lower its potency and stability over time.

Are my supplements still safe and/or effective if the package was left outside in the heat or cold for a couple of days?

Yes, there is no concern for safety or potency of your supplements if they were mistakenly left outside in the heat or cold for a short period of time (2-3 days), or for an extended period during shipping. It takes months of improper storage to negatively affect the quality of the product.

Is this product tested for lead, mercury, and other heavy metals?

Every batch of Healthy Directions’ products is tested for lead and heavy metals. Each is delivered to Healthy Directions with a Certificate of Analysis from the manufacturer stating that the products are free from heavy metals or within the limits set by California’s Proposition 65 – the most stringent in the country.

Does this product undergo independent laboratory testing?

Each month, Healthy Directions selects several of its products and sends them to independent laboratories to make sure that they meet safe levels for heavy metals as well as label claim. Each product is guaranteed to be tested at least once per year.