Super antioxidant shield fights free radicals at the cellular level to support healthy aging

Cardio-4 Super Antioxidants

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Was: $29.99
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Was: $119.96
Now: $74.97
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Was: $209.93
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Cardio-4 Super Antioxidants protects your heart, brain, and immune system and fights free-radical damage

  • Powerful antioxidant protection against free-radical damage to support healthy aging
  • Boosts levels of “master antioxidant” glutathione—critical for healthy mitochondria
  • Supports heart, brain, and immune system
  • Supports the body’s natural detoxification process
  • Developed by integrative cardiologist Dr. Stephen Sinatra

Throughout the day, your body’s natural defenses are bombarded by stress, poor diet, and more, all of which contribute to the creation of damaging free radicals. Antioxidants are your first line of defense to help neutralize these free radicals—which is crucial to maintaining overall health and well-being! That’s why I’ve often stressed the importance of a healthy diet full of antioxidant-rich fruits and vegetables. But I also know how difficult this can be to achieve. That’s why I also recommend supplementing with powerful antioxidants to help reduce oxidative stress caused by aging, everyday stress and activity, and environmental toxins.

My Cardio-4 Super Antioxidants is an antioxidant supplement for healthy aging that blends clinically researched “master antioxidant” glutathione and sour cherry with tried-and-true antioxidants green tea and pomegranate extracts. Together, they help provide added antioxidant support for your heart, brain, and immune system, and help to fight free-radical damage at the cellular level to support healthy aging and protect you throughout the day.

Cardio-4 Super Antioxidants features four of what I consider to be the key powerhouse antioxidants to provide you with this support every day! It truly is a one-of-a-kind combination of antioxidants you won’t find anywhere else.

Clinically researched "master antioxidant" glutathione

One of the most important antioxidants that your body naturally produces—glutathione—is crucial for keeping your cellular health in check. It helps support your cardiovascular and immune health, inflammatory balance, and brain and metabolic functions.1 That’s why it’s so vital you keep your glutathione levels up! Especially since your body’s stores of this potent antioxidant naturally decrease with age.2 The good news is glutathione antioxidant supplement Cardio-4 Super Antioxidants features a full clinical dose of Setria® glutathione that can help boost your levels of this essential antioxidant.

Known as the "master antioxidant," glutathione helps eliminate toxins and ingested chemicals that your body has absorbed. But what’s even more remarkable is its ability to intercept and neutralize toxins BEFORE they’re even able to be absorbed. Basically, glutathione is fighting free radicals, even before they can even do any damage! This in turn helps support your body’s natural detoxification process,3 helping to reduce oxidative stress and support a healthy inflammatory response—which is critical for maintaining a healthy heart and overall health.

PLUS, it also helps to regenerate other antioxidants, like vitamins C and E. Because as vitamins C and E are working to neutralize free radicals, they become unstable radicals themselves. Glutathione helps recycle or regenerate these unstable radicals, getting them back on the front line of defense against free radicals!4, 5

Clinically researched sour cherry

Primarily known as an ingredient for use in pies and baked goods, Montmorency tart cherries are now gaining recognition for their amazing health benefits, specifically around supporting a healthy inflammatory response and antioxidant protection. In fact, they’re now considered one of the top super fruits around!

That’s why I’ve included 100% natural and additive-free CherryPure® sour cherry powder in this antioxidant supplement for healthy aging. Produced from whole tart cherries using Good Agriculture and Manufacturing Practices, CherryPure is allergen and GMO-free, with no added ingredients, whereas other cherry powders may have as much as 15% fillers! And, it’s the ONLY tart cherry source backed by ingredient-specific clinical studies.

Plus, in a clinical study of younger athletes, it has been shown to help their recovery from intense athletic activity.6,7

To get all of these great benefits from a typical sour cherry juice, you’d have to drink 18 ounces of it, straight!

Tried-and-true pomegranate and green tea extracts

I’ve long shared how I recommend my non-inflammatory Pan-Asian Modified Mediterranean (PAMM) diet for a heart healthy lifestyle, and its suggested intake of antioxidant-rich fruits and vegetables. And pomegranate and green tea top the list! That’s why I’ve made sure to include both in this antioxidant supplement for healthy aging.

I’ve chosen Pomella® pomegranate extract since it’s a natural source of punicalagins—a class of polyphenols that are unique to pomegranate, and are metabolized by gut bacteria to promote antioxidant benefits.8 Laboratory studies suggest Pomella has a higher antioxidant capacity when compared to other polyphenol-rich supplements.9 And, it’s also highly bioavailable—this means Pomella can more easily be absorbed into your bloodstream, so its antioxidant properties can get straight to work!

In addition to pomegranate extract, I’ve rounded out this antioxidant supplement for healthy aging with a decaffeinated green tea extract. One of the major reasons green tea is so powerful is due its high concentration of one specific, very potent catechin polyphenol, called epigallocatechin gallate (EGCG).10 And, lab studies show that EGCG helps play an important role in supporting mitochondrial function in cells.11

A next generation, simple formula you won’t find anywhere else!

Just two capsules a day of Cardio-4 Super Antioxidants acts as a super antioxidant shield to fight free-radical damage at the cellular level to support healthy aging. It provides the added boost of antioxidant benefits you need to help your body neutralize free radicals and protect you each day. You won’t find this exact blend of clinically studied and tried-and-true antioxidants anywhere else!


1 Aquilano K, et al. Front Pharmacol. 2014;5:196.
2 Pizzorno JE, et al. J Restor Med. 2012;1:24–37.
3 Erden-Inal M, et al. Cell Biochem Funct. 2002;20:61–66.
4 Forman HJ, et al. Mol Aspects Med. 2009;30(1–2):1–12.
5 Pastore A, et al. Clin Chim Acta. 2003;333(1):19–39.
6 Levers K, et al. J Int Soc Sports Nutr. 2015;12:41.
7 Levers K, et al. J Int Soc Sports Nutr. 2016;13:22.
8 Yuan T, et al.ACS Chem Neurosci. 2016;7(1):26–33.
9 Henning SM, et al. J Agric Food Chem. 2014;62(19):4313–21.
10 Oliveira MR, et al. Pharmacol Res. 2016;104:70–85.
11 Kim H-S, et al. Redox Biol. 2014;2:187–95.

Super Antioxidants Shield Antioxidant levels

Dr. Sinatra Says:

Dr. Stephen Sinatra

"Throughout the day, your body’s natural defenses are bombarded by stress, poor diet, and more. Antioxidants are your first line of defense. One of the most important antioxidants, glutathione, is naturally produced by the body, but declines with age.

This "master antioxidant" is key for many cellular processes, as well as helping to support the function of your liver, kidneys, GI tract, and intestines—all of which are your body’s major detoxification pathways!—by helping to eliminate toxins and chemicals that the body has already absorbed. And, it helps to intercept and neutralize toxins in the GI tract before they’re even absorbed.

This is just one of the many reasons why I had to include glutathione in Cardio-4 Super Antioxidants. When it's combined with sour cherry, pomegranate, and green tea extracts, you get 4 powerful antioxidants in one simple formula—one that's so unique you won't find it anywhere else!"

Super Antioxidants Shield Antioxidant levels

Dr. Sinatra Says:

Dr. Stephen Sinatra

"Throughout the day, your body’s natural defenses are bombarded by stress, poor diet, and more. Antioxidants are your first line of defense. One of the most important antioxidants, glutathione, is naturally produced by the body, but declines with age.

This "master antioxidant" is key for many cellular processes, as well as helping to support the function of your liver, kidneys, GI tract, and intestines—all of which are your body’s major detoxification pathways!—by helping to eliminate toxins and chemicals that the body has already absorbed. And, it helps to intercept and neutralize toxins in the GI tract before they’re even absorbed.

This is just one of the many reasons why I had to include glutathione in Cardio-4 Super Antioxidants. When it's combined with sour cherry, pomegranate, and green tea extracts, you get 4 powerful antioxidants in one simple formula—one that's so unique you won't find it anywhere else!"

Ingredients and Dosage

Doctor's Suggested Use: Take 2 capsules once daily with a meal. For added support, take 2 capsules twice daily with meals.

Serving Size: 2 Capsules
Servings Per Container: 30

Ingredient Amount Per Serving % DV
CherryPURE®‡ Sour Cherry Powder (fruit) 480 mg *
Setria®§ Reduced L-Glutathione 250 mg *
Pomella®∫ Pomegranate Extract (fruit) 100 mg *
Green Tea Extract (leaf, decaffeinated) 100 mg *
* Daily Value (DV) not established

Other ingredients: Gelatin, magnesium stearate, silicon dioxide

Note: Pregnant or lactating women should consult a health care professional before taking this product.
Keep out of reach of children.

§ is a registered trademark of KYOWA HAKKO BIO Co., Ltd.
CherryPURE® is a registered trademark of Shoreline Fruit LLC.
Pomella® Extract is covered under U.S. Patent 7,638,640 and Pomella® is a registered trademark of Verdure Sciences, Inc.

Batch Information

Science and Quality

Setria® Glutathione: 250 mg per serving

A major cellular antioxidant, glutathione plays an important role in a multitude of cellular processes, including cell differentiation, proliferation, and viability. Optimal levels of glutathione support a number of systems including cardiovascular, inflammatory balance, immune health, metabolic functions, and brain function.1It’s important to note that your body’s stores of this potent antioxidant naturally decrease with age.2

  • Promotes a first line of defense against reactive oxygen species (ROS) by scavenging free radicals
  • Reduces oxidative stress markers
  • Increases body stores of glutathione
  • Recycles antioxidant vitamins C and E in cells, allowing them to maintain their antioxidant functions
  • Supports the body’s detoxification processes, a cofactor for several detoxifying enzyme systems3
  • Recycles antioxidant vitamins C and E in cells, allowing them to maintain their antioxidant functions4,5
  • Involved in both preventing and fighting free radicals

A 6-month randomized, double-blinded, placebo-controlled trial of 54 non-smoking adults showed glutathione reduces oxidative stress markers and increases body stores of glutathione. Glutathione levels in the blood and erythrocytes were measured after 1, 3, and 6 months vs. baseline.1

  • At 6 months, participants taking 250 mg/day of glutathione experienced a 17% increase in glutathione levels in their blood and 29% increase in glutathione levels in erythrocytes.
  • Additionally, a reduction in oxidative stress was found by decreases in the oxidized to reduced glutathione ratio in whole blood after 6 months. These results show for the first time that taking glutathione in an oral supplement reduces oxidative stress markers.

CherryPURE® SourCherry Powder 480 mg

CherryPURE™ is a sour or tart cherry powder produced from whole tart cherries that have been processed utilizing Good Agriculture and Manufacturing Practices from the orchard to the finished dried powder. The product contains no additional additives or excipients, is allergen and GMO free and meets US EPA Pesticide Residual allowances. It takes approximately 50 kg of whole cherries to make 1 kg of powder.

CherryPURE® Tart Cherry powder is the premier tart cherry material in the marketplace and the only tart cherry source backed by ingredient specific clinical studies. Texas A&M recently completed two sports nutrition based human clinical studies focusing on recovery from intense resistance and endurance training.7, 8

  • Helps support a healthy inflammatory balance
  • Supports the maintenance of muscle tissue (muscle function) with exertion
  • Increases total antioxidant status
  • Improves antioxidant defenses in healthy adults
  • Reduces muscle discomfort /soreness associated with intense exercise
  • Supports recovery following intense exercise
  • Supports functional performance on athletic tasks
  • Enhances melatonin levels and supports healthy sleep quality and duration

Pomella® Pomegranate extract 100 mg

Pomella® Pomegranate Extract is a standardized breakthrough formula of the primary natural antioxidants of the pomegranate fruit, punicalagins. It is 100% natural, highly bioavailable, high in antioxidants, and clinically researched. Contains no sugar, calories, or additives.

  • Has beneficial antioxidant effects
  • A source of punicalagins, a class of polyphenols that are metabolized by gut bacteria and promote antioxidant effects9
  • Laboratory studies suggest Pomella has a higher antioxidant capacity than numerous other polyphenol rich supplements10
  • Studies suggest punicalagins are highly bioavailable and confer antioxidant benefits

Green tea extract (decaffeinated) 100 mg

The green tea extract used in this product is standardized to polyphenols and is decaffeinated.

  • Polyphenols from green tea possess antioxidant properties
  • Green tea leaves are cultivated from the Camellia sinensis plant and are minimally oxidized. The leaves are prepared by steaming or drying fresh green tea leaves at elevated temperatures. Green tea maintains a rich concentration of catechin polyphenols.
  • The EGCG, one of the major bioactive polyphenols in green tea, is known to display powerful antioxidant properties and support cellular health.11
  • Laboratory studies show that EGCG plays an important role in supporting mitochondrial function in cells.12

1 Aquilano, K. et al. Front. Pharmacol. 5, 9196 (2014).
2 Pizzorno, J. E. et al. J. Restor. Med. 1, 24–37 (2012).
3 Erden-Inal, M., et al. Cell Biochem. Funct. 20, 61–66 (2002).
4 Forman, H. J., et al. Mol. Aspects Med. 30, 1–12 (2009).
5 Pastore, A. et al. Clin. Chim. Acta Int. J. Clin. Chem. 333, 19–39 (2003).
6 Richie, J. P. et al. Eur. J. Nutr. 54, 251–263 (2015).
7 Levers, K. et al. J. Int. Soc. Sports Nutr. 13, 22 (2016).
8 Levers, K. et al. J. J. Int. Soc. Sports Nutr. 12, 41 (2015).
9 Yuan, T. et al. ACS Chem. Neurosci. 7, 26-33 (2016).
10 Henning, S. M. et al. J. Agric. Food Chem. 62, 4313–431 (2014).
11 Oliveira, M. R. et al. Pharmacol. Res. 104, 70–85 (2016).
12 Kim, H.-S. et al. Redox Biol. 2, 187–195 (2014).