Grapefruit Juice and Medication Interaction

by Dr. Stephen Sinatra
Filed Under: General Health
Last Reviewed 03/21/2014

Grapefruit Juice and Medication Interaction

Grapefruit and its juice can create medication interactions with many types of drugs, from antibiotics to antipsychotics. These drugs should never be combined with grapefruit. Also, as a general rule, always remember to ask about any possible medication interactions with other drugs or foods whenever your doctor prescribes you a new medication.

Avoid Medication Interaction With Grapefruit


Aldosterone inhibitors:
eplerenone (Inspra)


Anti-arrhythmics
amiodarone (Cordarone) 
quinidine (Quinaglute, Quinidex, Quinora)


Antihypertensives
carvedilol (Coreg) 
losartan (Cozaar)


Blood thinners:
warfarin (Coumadin)


Calcium channel blockers
felodipine (Plendil) 
nicardipine (Cardene) 
nifedipine (Adalat, Procardia) 
nimodipine (Nimotop) 
isradipine (DynaCirc) 
verapamil (Isoptin, Verelan, Calan, Bosoptin, Covera-HS)


Statin drugs

atorvastatin (Lipitor) 
lovastatin (Mevacor) 
simvastatin (Zocor, Vytorin)


Anticonvulsants:
carbamazepine (Tegretol

Antidepressants
sertraline (Zoloft) 
trazodone (Desyrel) 
nefazodone (Serzone)
clomipramine (Anafranil)


Antihistamines
fexofenadine (Allegra)


Anti-anxiety drugs
diazepam (Valium) 
midazolam (Versed) 
triazolam (Halcion) 
buspirone (BuSpar)


Corticosteroids
methylprednisolone, oral (Medrol) 
budesonide (Pulmicort, Rhinocort)


Immunosuppressants
cyclosporine (Sandimmune, Neoral) 
tacrolimus (Prograf)


Protease inhibitors

ritonavir (Norvir) 
nelfinavir (Viracept) 
saquinavir (Invirase, Fortovase)

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